English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/147771
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Type 1 cannabinoid receptor mapping with [(18)F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism

AuthorsCasteels, Cindy; Martínez, Emili ; Bormans, G.; Camón, LLuïsa ; Vera, Núria de ; Baekelandt, Veerle; Planas, Anna M. ; van Laere, K.
KeywordsHuntington’s disease
Type 1 cannabinoid receptor
Small animal PET
Issue DateDec-2010
CitationEuropean Journal of Nuclear Medicine and Molecular Imaging 37(12): 2354-2363 (2010)
Abstract[Purpose] Several lines of evidence imply early alterations in metabolic, dopaminergic and endocannabinoid neurotransmission in Huntington’s disease (HD). Using [18F]MK-9470 and small animal PET, we investigated cerebral changes in type 1 cannabinoid (CB1) receptor binding in the quinolinic acid (QA) rat model of HD in relation to glucose metabolism, dopamine D2 receptor availability and amphetamine-induced turning behaviour.
[Methods] Twenty-one Wistar rats (11 QA and 10 shams) were investigated. Small animal PET acquisitions were conducted on a Focus 220 with approximately 18 MBq of [18F]MK-9470, [18F]FDG and [11C]raclopride. Relative glucose metabolism and parametric CB1 receptor and D2 binding images were anatomically standardized to Paxinos space and analysed voxel-wise using Statistical Parametric Mapping (SPM2).
[Results] In the QA model, [18F]MK-9470 uptake, glucose metabolism and D2 receptor binding were reduced in the ipsilateral caudate-putamen by 7, 35 and 77%, respectively (all p < 2.10−5), while an increase for these markers was observed on the contralateral side (>5%, all p < 7.10−4). [18F]MK-9470 binding was also increased in the cerebellum (p = 2.10−5), where it was inversely correlated to the number of ipsiversive turnings (p = 7.10−6), suggesting that CB1 receptor upregulation in the cerebellum is related to a better functional outcome. Additionally, glucose metabolism was relatively increased in the contralateral hippocampus, thalamus and sensorimotor cortex (p = 1.10−6).
[Conclusion] These data point to in vivo changes in endocannabinoid transmission, specifically for CB1 receptors in the QA model, with involvement of the caudate-putamen, but also distant regions of the motor circuitry, including the cerebellum. These data also indicate the occurrence of functional plasticity on metabolism, D2 and CB1 neurotransmission in the contralateral hemisphere.
Publisher version (URL)https://doi.org/10.1007/s00259-010-1574-2
Identifiersissn: 1619-7070
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.