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Joining time-resolved thermometry and magnetic-induced heating in a single nanoparticle unveils intriguing thermal properties

AuthorsPiñol, Rafael; Brites, Carlos; Bustamante, R.; Martínez, Abelardo; Silva, Nuno Joâo O.; Murillo, José Luis; Cases, Rafael; Carrey, J.; Estepa, L. C.; Sosa, Cecilia; Palacio, Fernando; Carlos, Luis D.; Millán, Ángel
KeywordsHeat diffusion
Magnetic hyperthermia
Intracellular temperature
Issue Date2015
PublisherAmerican Chemical Society
CitationACS Nano 9(3): 3134-3142 (2015)
AbstractWhereas efficient and sensitive nanoheaters and nanothermometers are demanding tools in modern bio- and nanomedicine, joining both features in a single nanoparticle still remains a real challenge, despite the recent progress achieved, most of it within the last year. Here we demonstrate a successful realization of this challenge. The heating is magnetically induced, the temperature readout is optical, and the ratiometric thermometric probes are dual-emissive Eu3+/Tb3+ lanthanide complexes. The low thermometer heat capacitance (0.021·K-1) and heater/thermometer resistance (1 K·W-1), the high temperature sensitivity (5.8%·K-1 at 296 K) and uncertainty (0.5 K), the physiological working temperature range (295-315 K), the readout reproducibility (>99.5%), and the fast time response (0.250 s) make the heater/thermometer nanoplatform proposed here unique. Cells were incubated with the nanoparticles, and fluorescence microscopy permits the mapping of the intracellular local temperature using the pixel-by-pixel ratio of the Eu3+/Tb3+ intensities. Time-resolved thermometry under an ac magnetic field evidences the failure of using macroscopic thermal parameters to describe heat diffusion at the nanoscale.
Identifiersdoi: 10.1021/acsnano.5b00059
e-issn: 1936-086X
issn: 1936-0851
Appears in Collections:(ICMA) Artículos
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