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Title

Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier

AuthorsMoros, María; Grazú, Valeria; Fuente, Jesús M. de la; Teixidó, Meritxell; Giralt, Ernest
KeywordsBlood–brain barrier
Enantioselectivity
Membranes
Peptides
Receptors
Issue Date2015
PublisherWiley-VCH
CitationAngewandte Chemie International Edition 54(13): 3967-3972 (2015)
AbstractThe blood-brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain. In fact, less than 2 % of all potential neurotherapeutics are able to cross it. Here, by applying the retro-enantio approach to a peptide that targets the transferrin receptor, a full protease-resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.
URIhttp://hdl.handle.net/10261/147543
DOI10.1002/anie.201411408
Identifiersdoi: 10.1002/anie.201411408
e-issn: 1521-3773
e-issn: 1433-7851
Appears in Collections:(ICMA) Artículos
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