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Title

POMC: An evolutionary perspective

AuthorsNavarro, S. ; Soletto, L.; Puchol, Sara; Rotllant, Josep ; Soengas, José L.; Cerdá-Reverter, José Miguel
KeywordsACTH
β-endorphin
Opioid
Evolution
MSH
Proopiomelanocortin
Issue Date1-May-2016
PublisherSociety for Endocrinology
CitationJournal of Molecular Endocrinology 56: T113-T118 (2016)
AbstractProopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.
Publisher version (URL)https://doi.org/10.1530/JME-15-0288
URIhttp://hdl.handle.net/10261/145650
DOI10.1530/JME-15-0288
Identifiersissn: 1479-6813
Appears in Collections:(IIM) Artículos
(IATS) Artículos
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