English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/144748
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish

AuthorsGarcía-García, María; Liarte, Sergio; Gómez-González, Nuria E.; García-Alcázar, Alicia; Pérez-Sánchez, Jaume ; Meseguer, José; Mulero, Victoriano; García-Ayala, Alfonsa; Chaves-Pozo, Elena
KeywordsCimetidine
Hermaphrodite fish
Testis
Histamine receptors
Issue DateNov-2016
PublisherElsevier
CitationComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 189: 44-53 (2016)
AbstractThe importance of histamine in the physiology of the testis in mammals and reptiles has been recently shown. Histamine receptors (Hrs) are well conserved in fish and are functional in several fish species. We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream. Moreover, cimetidine, which acts in vitro as an agonist of Hrh1 and Hrh2 on this species, was intraperitoneally injected in one and two years old gilthead seabream males. After three and five days of cimetidine injection, we found that this compound differently modified the gonadal hrs transcript levels and affects the testicular cell renewal and the gene expression of steroidogenesis-related molecules as well as the serum steroid levels. Our data point to cimetidine as a reproductive disruptor and elucidate a role for histamine in the gonad of this hermaphrodite fish species through Hr signalling.
Publisher version (URL)https://doi.org/10.1016/j.cbpc.2016.07.004
URIhttp://hdl.handle.net/10261/144748
DOI10.1016/j.cbpc.2016.07.004
Identifiersissn: 1878-1659
Appears in Collections:(IATS) Artículos
Files in This Item:
File Description SizeFormat 
2016 Cimetidine disrupts the renewal.pdf541,32 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.