Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/144484
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The forebrain-midbrain acts as functional endocrine signaling pathway of kiss2/gnrh1 system controlling the gonadotroph activity in the teleost fish european sea bass (dicentrarchus labrax) |
Autor: | Espigares, F. CSIC ORCID; Carrillo, Manuel CSIC ORCID; Gómez, Ana CSIC ORCID; Zanuy, Silvia CSIC ORCID | Palabras clave: | Teleost fish Sperm quality Kisspeptin Intracerebroventricular injection Gonadotropin-releasing hormone Forebrain-midbrain |
Fecha de publicación: | 1-mar-2015 | Editor: | Society for the Study of Reproduction | Citación: | Biology of Reproduction 92 (2015) | Resumen: | Some teleost species, including European sea bass, harbor two different kisspeptin coding genes: kiss1 and kiss2. Both genes are expressed in the brain, but their differential roles in the central control of fish reproduction are only beginning to be elucidated. In this study, we have examined the effects of intracerebroventricular injections of the highly active sea bass peptides Kiss1-15 and Kiss2-12 on spermiating male sea bass. Physiological saline, Kiss1-15, or Kiss2-12 was injected into the third ventricle. To establish the gene expression cascade involved in the action of kisspeptins, the expression of the two sea bass kisspeptin receptor genes (kiss1r and kiss2r) and the three sea bass Gnrh genes (gnrh1, gnrh2, and gnrh3) were analyzed in the forebrain-midbrain and the hypothalamus. In addition, the protein levels of hypothalamic and pituitary Gnrh1 were measured. Blood samples were collected at different times after injection to analyze the effects of kisspeptins on the release of gonadotropins (Lh and Fsh) and androgens (testosterone and 11-ketotestosterone). The present results provide the first evidence that the effects of Kiss2 on central regulation of reproductive function involve the neuroendocrine areas of the forebrain-midbrain in teleost fish. The marked effect of Kiss2 on kiss2r and gnrh1 expression in the forebrain-midbrain and on Gnrh1 release suggest that this neuronal system is involved in the neuroendocrine regulation of gonadotroph activity. This hypothesis was confirmed by a surge of plasma Lh in response to Kiss2, which presumably has a strong stimulatory effect on testosterone release, and thus on sperm quality parameters. | Versión del editor: | https://doi.org/10.1095/biolreprod.114.125138 | URI: | http://hdl.handle.net/10261/144484 | DOI: | 10.1095/biolreprod.114.125138 | Identificadores: | issn: 1529-7268 |
Aparece en las colecciones: | (IATS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
42
checked on 13-mar-2024
WEB OF SCIENCETM
Citations
37
checked on 27-feb-2024
Page view(s)
161
checked on 28-mar-2024
Download(s)
56
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.