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SPOC: A widely distributed domain associated with cancer, apoptosis and transcription

AutorSánchez-Pulido, Luis; Rojas, A. M. ; Van Wely, Karel H. M.; Martínez-Alonso, Carlos; Valencia, Alfonso
Fecha de publicación8-jul-2004
EditorBioMed Central
CitaciónBMC Bioinformatics 5: 91 (2004)
Resumen[Background] The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.
[Results] We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods.
[Conclusions] The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.
Versión del editorhttp://doi.org/10.1186/1471-2105-5-91
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