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dc.contributor.authorFuente, José de la-
dc.contributor.authorKocan, Katherine M.-
dc.contributor.authorBlouin, Edmour F.-
dc.contributor.authorZivkovic, Zorica-
dc.contributor.authorNaranjo, María Victoria-
dc.contributor.authorAlmazán, Consuelo-
dc.contributor.authorJongejan, Frans-
dc.contributor.authorMangold, Atilio J.-
dc.date.accessioned2017-02-17T13:00:54Z-
dc.date.available2017-02-17T13:00:54Z-
dc.date.issued2010-
dc.identifierdoi: 10.1016/j.vetpar.2009.09.019-
dc.identifierissn: 0304-4017-
dc.identifiere-issn: 1873-2550-
dc.identifier.citationVeterinary Parasitology 167(2-4): 175-186 (2010)-
dc.identifier.urihttp://hdl.handle.net/10261/144221-
dc.description.abstractThe genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.-
dc.description.sponsorshipThis research was supported by the Ministerio de Ciencia e Innovación, Spain (project BFU2008-01244/BMC), the European Community, INCO-DEV program (project no. 003713) and the Oklahoma Agricultural Experiment Station (project 1669) and was facilitated through the Integrated Consortium on Ticks and Tick-borne Diseases (ICTTD-3), financed by the International Cooperation Program of the European Union, coordination action project No. 510561. V. Naranjo was funded by European Social Fund and Junta de Comunidades de Castilla-La Mancha (Program FSE 2007-2013), Spain.-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.subjectGenomics-
dc.subjectAnaplasma-
dc.subjectRNA interference-
dc.subjectMajor surface protein-
dc.subjectVaccine-
dc.subjectEvolution-
dc.titleFunctional genomics and evolution of tick-Anaplasma interactions and vaccine development-
dc.typeartículo-
dc.identifier.doi10.1016/j.vetpar.2009.09.019-
dc.date.updated2017-02-17T13:00:55Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderJunta de Comunidades de Castilla-La Mancha-
dc.contributor.funderEuropean Commission-
dc.contributor.funderOklahoma State University-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100007069es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011698es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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