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http://hdl.handle.net/10261/144221
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fuente, José de la | - |
dc.contributor.author | Kocan, Katherine M. | - |
dc.contributor.author | Blouin, Edmour F. | - |
dc.contributor.author | Zivkovic, Zorica | - |
dc.contributor.author | Naranjo, María Victoria | - |
dc.contributor.author | Almazán, Consuelo | - |
dc.contributor.author | Jongejan, Frans | - |
dc.contributor.author | Mangold, Atilio J. | - |
dc.date.accessioned | 2017-02-17T13:00:54Z | - |
dc.date.available | 2017-02-17T13:00:54Z | - |
dc.date.issued | 2010 | - |
dc.identifier | doi: 10.1016/j.vetpar.2009.09.019 | - |
dc.identifier | issn: 0304-4017 | - |
dc.identifier | e-issn: 1873-2550 | - |
dc.identifier.citation | Veterinary Parasitology 167(2-4): 175-186 (2010) | - |
dc.identifier.uri | http://hdl.handle.net/10261/144221 | - |
dc.description.abstract | The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens. | - |
dc.description.sponsorship | This research was supported by the Ministerio de Ciencia e Innovación, Spain (project BFU2008-01244/BMC), the European Community, INCO-DEV program (project no. 003713) and the Oklahoma Agricultural Experiment Station (project 1669) and was facilitated through the Integrated Consortium on Ticks and Tick-borne Diseases (ICTTD-3), financed by the International Cooperation Program of the European Union, coordination action project No. 510561. V. Naranjo was funded by European Social Fund and Junta de Comunidades de Castilla-La Mancha (Program FSE 2007-2013), Spain. | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.subject | Genomics | - |
dc.subject | Anaplasma | - |
dc.subject | RNA interference | - |
dc.subject | Major surface protein | - |
dc.subject | Vaccine | - |
dc.subject | Evolution | - |
dc.title | Functional genomics and evolution of tick-Anaplasma interactions and vaccine development | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.vetpar.2009.09.019 | - |
dc.date.updated | 2017-02-17T13:00:55Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Junta de Comunidades de Castilla-La Mancha | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Oklahoma State University | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100007069 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011698 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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