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http://hdl.handle.net/10261/143754
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Hernández-Tiedra, Sonia | es_ES |
dc.contributor.author | Boya, Patricia | es_ES |
dc.contributor.author | Velasco, Guillermo | es_ES |
dc.date.accessioned | 2017-02-10T10:39:18Z | - |
dc.date.available | 2017-02-10T10:39:18Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | Autophagy 12(11):2213-2229 (2016) | es_ES |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | http://hdl.handle.net/10261/143754 | - |
dc.description | 19 p.-7 fig. Hernández-Tiedra, Sonia et al. | es_ES |
dc.description.abstract | Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main active component of marijuana, a compound that triggers autophagy-mediated cancer cell death) and nutrient deprivation (an autophagic stimulus that triggers cytoprotective autophagy) to investigate the precise molecular mechanisms responsible for the activation of cytotoxic autophagy in cancer cells. By using a wide array of experimental approaches we show that THC (but not nutrient deprivation) increases the dihydroceramide:ceramide ratio in the endoplasmic reticulum of glioma cells, and this alteration is directed to autophagosomes and autolysosomes to promote lysosomal membrane permeabilization, cathepsin release and the subsequent activation of apoptotic cell death. These findings pave the way to clarify the regulatory mechanisms that determine the selective activation of autophagy-mediated cancer cell death. | es_ES |
dc.description.sponsorship | This work has been funded by the PI15/00339 grant, integrated into the State Plan for R & D C I2013–2016 and funded by the Instituto de salud Carlos III (ISCIII) and the European Regional Development Fund (ERDF) and by grants from Spanish Ministry of Economy and Competitiveness (MINECO)/ISCIII and ERDF (PS09/01401; PI12/02248, FR2009–0052 and IT2009-0053 to GV; SAF2011-22444 to GF, BFU2012-36241 to FMG,BFU2011-28566 to AA), Comunidad de Madrid (S2011/BMD-2308 to MG), Fundaci on Mutua Madrileña (AP101042012 to GV) and “Fundació La Marató de TV3” (20134031 to GV). Generalitat de Catalunya (2009SGR1072 to GF) Basque Government (IT830-13 to AA, IT849-13 to FMG) and SAF2012-36079 from MINECO and PIE 201320E071 from CSIC to PB. Part of the work at G Velasco laboratory is funded by GW Pharma Ltd. Work in the UK was supported by The British Skin Foundation.Work in MJ laboratory was supported by the Danish NationalResearch Foundation (DNRF125), the European Research Council (AdG 340751), the Danish Cancer Society (R90-A5783), and the Danish Medical Research Council (10-083790). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Taylor & Francis | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Autophagy | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Cannabinoids | es_ES |
dc.subject | Cell death | es_ES |
dc.subject | Sphingolipids | es_ES |
dc.title | Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1080/15548627.2016.1213927 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1080/15548627.2016.1213927 | es_ES |
dc.identifier.e-issn | 1554-8635 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Fundación Mutua Madrileña | es_ES |
dc.contributor.funder | Fundació La Marató de TV3 | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.contributor.funder | Eusko Jaurlaritza | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | es_ES |
dc.contributor.funder | GW Pharmaceuticals | es_ES |
dc.contributor.funder | British Skin Foundation | es_ES |
dc.contributor.funder | Danish National Research Foundation | es_ES |
dc.contributor.funder | European Research Council | es_ES |
dc.contributor.funder | Danish Cancer Society Research Center | es_ES |
dc.contributor.funder | Danish Medical Research Council | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008061 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008666 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000296 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001732 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003086 | es_ES |
dc.identifier.pmid | 27635674 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Autophagy 2016.pdf | Artículo principal | 2,43 MB | Adobe PDF | Visualizar/Abrir |
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