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Title

Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

AuthorsMarques, Joana; Valle-Delgado, Juan J.; Urbán, Patricia; Baró, Elisabet; Prohens, Rafel; Mayor, Alfredo; Cisteró, Pau; Delves, Michael; Sinden, Robert E.; Grandfils, Christian; Paz, José L. de; García-Salcedo, José A.; Fernández-Busquets, Xavier
KeywordsGlycosaminoglycans
Malaria
Nanomedicine
Plasmodium
Targeted drug delivery
Issue Date2017
PublisherElsevier
CitationNanomedicine - Nanotechnology Biology and Medicine, 13:515-525 (2017)
AbstractThe adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems
Publisher version (URL)http://dx.doi.org/10.1016/j.nano.2016.09.010
URIhttp://hdl.handle.net/10261/143357
DOI10.1016/j.nano.2016.09.010
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