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Title

A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function

AuthorsTristán Clavijo, E. ; Camacho García, R. J. ; Robles Lanuza, Estefanía ; Ruiz, Agustín; van der Zee, Julie; van Broeckhoven, Christine; Hernández, Isabel; Martínez Mir, Amalia ; Scholl, Francisco G.
KeywordsAlzheimer's disease
NLGN1
Synapse
Mutation
Neuroligin
Issue DateDec-2015
PublisherElsevier
CitationNeurobiology of Aging 36(12): 3171-3175 (2015)
AbstractNeuroligins (NLs) are cell-adhesion proteins that regulate synapse formation and function. Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation in mouse models. Thus, altered NL1 function could mediate the synaptic and memory deficits associated with Alzheimer's disease (AD). Here, we describe a frameshift mutation, c.875_876insTT, in the neuroligin 1 gene (NLGN1) in a patient with AD and familial history of AD. The insertion generates a premature stop codon in the extracellular domain of NL1 (p.Thr271fs). Expression of mutant NL1 shows accumulation of truncated NL1 proteins in the endoplasmic reticulum. In hippocampal neurons, the p.Thr271fs mutation abolishes the ability of NL1 to promote the formation of glutamatergic synapses. Our data support a role for inactivating mutations in NLGN1 in AD. Previous studies have reported rare mutations in X-linked NLGNL3 and NLGNL4 genes in patients with autism, which result in the inactivation of the mutant alleles. Therefore, together with a role in neurodevelopmental disorders, altered NL function could underlie the molecular mechanisms associated with brain diseases in the elderly.
Publisher version (URL)http://doi.org/10.1016/j.neurobiolaging.2015.09.004
URIhttp://hdl.handle.net/10261/143264
DOI10.1016/j.neurobiolaging.2015.09.004
Identifiersissn: 1558-1497
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