English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/143254
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice

AuthorsRabaneda, Luis G. ; Robles Lanuza, Estefanía ; Nieto-González, J.; Scholl, Francisco G.
Issue Date24-Jul-2014
PublisherElsevier
CitationCell Reports 8(2): 338-346 (2014)
AbstractAutism spectrum disorders (ASDs) comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits. Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early postnatal periods result in aberrant wiring and function of neuronal circuits. Neurexins are synaptic proteins associated with autism. Here, we generated transgenic βNrx1δC mice in which neurexin function is selectively impaired during late postnatal stages. Whole-cell recordings in cortical neurons show an impairment of glutamatergic synaptic transmission in the βNrx1δC mice. Importantly, mutant mice exhibit autism-related symptoms, such as increased self-grooming, deficits in social interactions, and altered interaction for nonsocial olfactory cues. The autistic-like phenotype of βNrx1δC mice can be reversed after removing the mutant protein in aged animals. The defects resulting from disruption of neurexin function after the completion of embryonic and early postnatal development suggest that functional impairment of mature circuits can trigger autism-related phenotypes. © 2014 The Authors.
Publisher version (URL)http://doi.org/10.1016/j.celrep.2014.06.022
URIhttp://hdl.handle.net/10261/143254
DOI10.1016/j.celrep.2014.06.022
Identifiersissn: 2211-1247
Appears in Collections:(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
neurexin_dysfunction_Rabaneda.pdf2,13 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.