Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/143209COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | A comparison of brain gene expression levels in domesticated and wild animals |
Autor: | Albert, Frank W.; Carneiro, Miguel; Blanco-Aguiar, José Antonio CSIC ORCID; Villafuerte, Rafael CSIC ORCID; Ferrand, Nuno | Fecha de publicación: | 2012 | Editor: | Public Library of Science | Citación: | PLoS Genetics 8(9): e1002962 (2012) | Resumen: | Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs and a distant wild relative (Cavia aperea) as well as between two lines of rats selected for tameness or aggression towards humans. There were few gene expression differences between domesticated and wild dogs, pigs, and rabbits (30-75 genes (less than 1%) of expressed genes were differentially expressed), while guinea pigs and C. aperea differed more strongly. Almost no overlap was found between the genes with differential expression in the different domestication events. In addition, joint analyses of all domesticated and wild samples provided only suggestive evidence for the existence of a small group of genes that changed their expression in a similar fashion in different domesticated species. The most extreme of these shared expression changes include up-regulation in domesticates of SOX6 and PROM1, two modulators of brain development. There was almost no overlap between gene expression in domesticated animals and the tame and aggressive rats. However, two of the genes with the strongest expression differences between the rats (DLL3 and DHDH) were located in a genomic region associated with tameness and aggression, suggesting a role in influencing tameness. In summary, the majority of brain gene expression changes in domesticated animals are specific to the given domestication event, suggesting that the causative variants of behavioral domestication traits may likewise be different. | Descripción: | This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al. | Versión del editor: | http://dx.doi.org/10.1371/journal.pgen.1002962 | URI: | http://hdl.handle.net/10261/143209 | DOI: | 10.1371/journal.pgen.1002962 | Identificadores: | doi: 10.1371/journal.pgen.1002962 issn: 1553-7390 e-issn: 1553-7404 |
| Aparece en las colecciones: | (IREC) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| DomesticatedWild.PDF | 726,49 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
61
checked on 08-abr-2024
SCOPUSTM
Citations
104
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
98
checked on 25-feb-2024
Page view(s)
288
checked on 24-abr-2024
Download(s)
287
checked on 24-abr-2024
