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Title

Genotoxic activity of halogenated phenylglycine derivatives

AuthorsBoto, Alicia CSIC ORCID ; Gallardo, Juan Antonio CSIC; Hernández, Rosendo CSIC; Ledo, Francisco; Muñoz, Ana; Murguía, José Ramón CSIC ORCID; Menacho-Márquez, Mauricio CSIC; Orjales, Aurelio; Saavedra, Carlos Javier
KeywordsCytotoxic
Genotoxic
Amino acids
Phenylglycine
Cancer
Issue Date20-Sep-2006
PublisherElsevier
CitationBioorganic and Medicinal Chemistry Letters 16(23): 6073-6077 (2006)
AbstractThe discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.
Description5 pages, 4 figures, 5 schemes.-- PMID: 16990000 [PubMed].-- Printed version published Dec 1, 2006.
Supporting information available: Spectroscopic data for selected compounds, other cytotoxic activities, materials and general procedures for the determination of the cytotoxic activity and the mechanism of action studies.-- Available at: http://dx.doi.org/10.1016/j.bmcl.2006.08.111
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2006.08.111
URIhttp://hdl.handle.net/10261/14309
DOI10.1016/j.bmcl.2006.08.111
ISSN0960-894X
Appears in Collections:(IBMCP) Artículos
(IPNA) Artículos

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