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| Title: | Genotoxic activity of halogenated phenylglycine derivatives |
Authors: | Boto, Alicia CSIC ORCID ; Gallardo, Juan Antonio CSIC; Hernández, Rosendo CSIC; Ledo, Francisco; Muñoz, Ana; Murguía, José Ramón CSIC ORCID; Menacho-Márquez, Mauricio CSIC; Orjales, Aurelio; Saavedra, Carlos Javier | Keywords: | Cytotoxic Genotoxic Amino acids Phenylglycine Cancer |
Issue Date: | 20-Sep-2006 | Publisher: | Elsevier | Citation: | Bioorganic and Medicinal Chemistry Letters 16(23): 6073-6077 (2006) | Abstract: | The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae. | Description: | 5 pages, 4 figures, 5 schemes.-- PMID: 16990000 [PubMed].-- Printed version published Dec 1, 2006. Supporting information available: Spectroscopic data for selected compounds, other cytotoxic activities, materials and general procedures for the determination of the cytotoxic activity and the mechanism of action studies.-- Available at: http://dx.doi.org/10.1016/j.bmcl.2006.08.111 |
Publisher version (URL): | http://dx.doi.org/10.1016/j.bmcl.2006.08.111 | URI: | http://hdl.handle.net/10261/14309 | DOI: | 10.1016/j.bmcl.2006.08.111 | ISSN: | 0960-894X |
| Appears in Collections: | (IBMCP) Artículos (IPNA) Artículos |
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