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Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

AuthorsTurroni, Francesca; Taverniti, Valentina; Ruas-Madiedo, Patricia ; Duranti, Sabrina; Guglielmetti, S.; Lugli, Gabriele Andrea; Gioiosa, Laura; Palanza, Paola; Margolles Barros, Abelardo ; Van Sinderen, Douwe; Ventura, Marco
Issue DateJan-2014
PublisherAmerican Society for Microbiology
CitationApplied and Environmental Microbiology 80: 730-740 (2014)
AbstractHere, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NFκB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host. © 2014, american Society for Microbiology. All Rights Reserved.
Publisher version (URL)https://doi.org/10.1128/AEM.03313-13
Identifiersissn: 0099-2240
Appears in Collections:(IPLA) Artículos
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