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The human DNA damage response network database of proteins

AuthorsLeón, Eduardo Andrés; Cases, Ildefonso; Rojas, A. M.
Issue DateSep-2014
CitationXXXVII Congreso de la Sociedad Española de Bioquímica y Biología Molecular (2014)
AbstractThe DNA damage response (DDR) is an essential signaling network that protects the integrity of the genome. This network is built upon a repertoire of distinct but often overlapping sub-networks, where sometimes the same components have different roles in precise spatial and temporal scenarios. Perturbations of this network produce genomic instability, which is inherently related to aging (Fernandez-Capetillo 2010), disease (Ciccia and Elledge 2010), and cancer, reviewed in (Lukas, Lukas et al. 2011). Despite its importance, evolutionary studies addressing the emergence of this network were restricted to few protein families (On, Xiong et al. 2010). In this line, we have recently provided the largest systematic analyses of the human DDR network and have analysed its evolutionary properties (Arcas, Fernandez-Capetillo et al. 2014). To complement this study, we have built a resource to explore these data, in an evolutionary context. From this database, it is possible to select genes according with its function in a particular pathway or network, according with post translational modifications (PTMs) where the gene acts as a target or a modifier and also by sequence similarity. When searching for PTMs, affected residues and links to Pubmed articles are provided. In this tool, it is easy to find DDR proteins that emerged at the same age, or involved in same networks/pathways, and also affected by similar PTM modifiers. When a DDR protein is selected, a detailed view displays information regarding its emergence and conservation across 47 species, the overall agreement with the taxonomic tree, and the position of a post- translationaly modified residue in a structure when available. This resource is available at: http://ddr.cbbio.es.
DescriptionPóster presentado en el XXXVII Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM), celbrado en Granada del 9 al 12 de septiembre de 2014.
Appears in Collections:(IBIS) Comunicaciones congresos
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