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Closed Access item HDAC and Hsp90 Inhibitors Down-Regulate PTTG1/Securin But Do Not Induce Aneuploidy

Authors:López-Lluch, Guillermo
Hernández, Agustín
Navas, Plácido
Pintor-Toro, José Antonio
Keywords:HDAC, Hsp90, Inhibitors
Issue Date:11-Nov-2008
Citation:Genes, Chromosomes & Cancer 48 (2) :194–201 (2009)
Abstract:Human securin regulates correct chromatid separation. However, there are conflicting reports on the aneugenic effects of its gene deletion. Here we show that PTTG1/securin gene expression is dramatically repressed when Hsp90 or histone deacetylases are inhibited. However, these treatments do not increase the proportion of aneuploid cells. This was also confirmed using RNAi (silencing of PTTG1/securin 80%). As expected, histone deacetylases arrested cells in both G1 and G2. However, sec-/- HCT116 cells showed a greater disposition to arrest cells in G2 than sec+/+ cells due to insufficient induction of CDKN1A. These results indicate that chromatid separation is controlled through redundant mechanisms and reveal a new aspect of securin in cell cycle regulation
Publisher version (URL):http://dx.doi.org/10.1002/gcc.20630
ISSN:1098-2264 (Online)
1045-2257 (Print)
Appears in Collections:(CABD) Artículos
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