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Título: | New carbamate supports for the preparation of 3'-amino-modified oligonucleotides |
Autor: | Aviñó, Anna CSIC ORCID; Güimil García, Ramón; Albericio, Fernando CSIC ORCID; Mann, Matthias; Wilm, Matthias S.; Neubauer, Gitte; Eritja Casadellà, Ramón CSIC ORCID | Palabras clave: | Carbamic acid Oligonucleotides Chemical modification Mass Spectrometry |
Fecha de publicación: | oct-1996 | Editor: | Elsevier | Citación: | Bioorganic and Medicinal Chemistry 4(10):1649-1658 (1996) | Resumen: | A novel approach for the preparation of oligonucleotides carrying amino groups at the 3'-end is described. Several CPG supports having aminoalkyl groups and 3'-amino-2',3'-dideoxynucleosides linked through base-labile carbamate linkages such as 2-(2- nitrophenyl)ethoxycarbonyl and fluorenylmethoxycarbonyl were prepared using two different strategies. These supports are compatible to the standard solid phase phosphite-triester methodology and yield oligonucleotides containing amino groups at the 3'-end. Several properties of the 3'-amino oligonucleotides, such as nuclease resistance, hybridization, and preparation of oligonucleotide conjugates are discussed. | Versión del editor: | 10.1016/0968-0896(96)00156-3 | URI: | http://hdl.handle.net/10261/141159 | DOI: | 10.1016/0968-0896(96)00156-3 |
Aparece en las colecciones: | (IQAC) Artículos |
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Avino1996BMCcarbamate.pdf | 484,91 kB | Adobe PDF | Visualizar/Abrir |
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