English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/140410
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Drugs of environmental concern modify Solea senegalensis physiology and biochemistry in a temperature-dependent manner

AuthorsGonzález-Mira, A.; Varó, Inmaculada ; Solé, Montserrat ; Torreblanca, Amparo
KeywordsSole
Plasma metabolites
CYP enzymes
Anti-oxidant enzymes
HSP70
Ibuprofen
Carbamazepine
Issue DateOct-2016
PublisherSpringer
CitationEnvironmental Science and Pollution Research 23(20): 20937-20951 (2016)
AbstractThe alerted presence in recent decades of pharmaceuticals has become an issue of environmental concern, and most of the mechanisms of biotransformation and biochemical and physiological responses to them in fish are still unknown, as well as the influence of water temperature in their ability to cope with them. This study aims to detect the main effects of two of the most widespread drugs on a set of physiological and biochemical markers in Solea senegalensis. Sole juveniles acclimatized at 15 and 20 °C were administered an intraperitoneal injection of the non-steroidal anti-inflammatory drug ibuprofen (IB; 10 mg/kg) and the anti-convulsant drug carbamazepine (CBZ; 1 mg/kg). Two days after the injection, liver, muscle and plasma were sampled. Liver enzymatic activities of 15 °C acclimated fish were more responsive to pharmaceuticals than those acclimated at 20 °C, especially for CYP450-related activities (7-ethoxyresorufin (EROD), 7-methoxyresorufin (MROD), 3-cyano-7-ethoxycoumarin (CECOD) and 7-benzyloxy-4-[trifluoromethyl]-coumarin-O-debenzyloxylase (BFCOD)) and uridine diphosphate glucuronosyltransferase (UDPGT). Cytosolic anti-oxidant enzyme activities and glutathione S-transferase (GST) did not show a clear effect of temperature. Glucose and transferase activities in plasma were not affected by the treatments, while ammonium, osmolality and lactate were affected by both pharmaceuticals. Plasma triglycerides were affected in a temperature-dependent manner, and creatinine was only responsive to CBZ injection. HSP70 levels in muscle were only affected by CBZ injection. Some of the physiological identified responses to IB and CBZ are proposed as endpoints in further chronic studies
DescriptionSpecial issue Chemical, Energy and Environmental Engineering.-- 11 pages, 4 figures, 5 tables
Publisher version (URL)https://dx.doi.org/10.1007/s11356-016-7293-x
URIhttp://hdl.handle.net/10261/140410
DOI10.1007/s11356-016-7293-x
Identifiersdoi: 10.1007/s11356-016-7293-x
issn: 0944-1344
e-issn: 1614-7499
Appears in Collections:(IATS) Artículos
(ICM) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.