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dc.contributor.authorBurdío, Fernando-
dc.contributor.authorBerjano, Enrique J.-
dc.contributor.authorNavarro, Ana-
dc.contributor.authorBurdío, José M.-
dc.contributor.authorGrande, Luis-
dc.contributor.authorSubirá, Jorge-
dc.contributor.authorCastiella, Tomás-
dc.contributor.authorPoves, Ignasi-
dc.contributor.authorLequerica, Juan L.-
dc.identifier.citationBioMedical Engineering OnLine 2009, 8:6en_US
dc.description10 pages, 8 figures, 2 tables and 1 additional file.en_US
dc.description.abstract[Background] Efficient and safe transection of biological tissue in liver surgery is strongly dependent on the ability to address both parenchymal division and hemostasis simultaneously. In addition to the conventional clamp crushing or finger fracture methods other techniques based on radiofrequency (RF) currents have been extensively employed to reduce intraoperative blood loss. In this paper we present our broad research plan for a new RF-assisted device for bloodless, rapid resection of the liver.en_US
dc.description.abstract[Methods] Our research plan includes computer modeling and in vivo studies. Computer modeling was based on the Finite Element Method (FEM) and allowed us to estimate the distribution of electrical power deposited in the tissue, along with assessing the effect of the characteristics of the device on the temperature profiles. Studies based on in vivo pig liver models provided a comparison of the performance of the new device with other techniques (saline-linked technology) currently employed in clinical practice. Finally, the plan includes a pilot clinical trial, in which both the new device and the accessory equipment are seen to comply with all safety requirements.en_US
dc.description.abstract[Results] The FEM results showed a high electrical gradient around the tip of the blade, responsible for the maximal increase of temperature at that point, where temperature reached 100°C in only 3.85 s. Other hot points with lower temperatures were located at the proximal edge of the device. Additional simulations with an electrically insulated blade produced more uniform and larger lesions (assessed as the 55°C isotherm) than the electrically conducting blade. The in vivo study, in turn, showed greater transection speed (3 ± 0 and 3 ± 1 cm2/min for the new device in the open and laparoscopic approaches respectively) and also lower blood loss (70 ± 74 and 26 ± 34 mL) during transection of the liver, as compared to saline-linked technology (2 ± 1 cm2/min with P = 0.002, and 527 ± 273 mL with P = 0.001).en_US
dc.description.sponsorshipThis work was partially supported by a medical research grant from the Spanish Government (PETRI 2005/0353), from the "Programa de Promoción de la Investigación Biomédica y en Ciencias de la Salud del Ministerio de Sanidad y Consumo" of Spain (PI052498), and by the "Spanish Plan Nacional de I+D+I del Ministerio de Ciencia e Innovación" (TEC2008-01369/TEC). Finally, the publication cost were provided by the "Programa de Apoyo a la Investigación y el Desarrollo" of the Universidad Politécnica de Valencia.en_US
dc.format.extent1235434 bytes-
dc.publisherBioMed Centralen_US
dc.relation.isversionofPublisher’s version-
dc.subjectAssisted deviceen_US
dc.titleResearch and development of a new RF-assisted device for bloodless rapid transection of the liver: Computational modeling and in vivo experimentsen_US
dc.description.peerreviewedPeer revieweden_US
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