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Title

Recombination in viruses: Mechanisms, methods of study, and evolutionary consequences

AuthorsPérez-Losada, Marcos; Arenas, Miguel ; Galán, Juan Carlos; Palero, Ferran ; González-Candelas, Fernando
KeywordsReassortment
Recombination
Population structure
Recombination rate
Mutation rate
Linkage disequilibrium
Issue Date23-Dec-2015
PublisherElsevier
CitationInfection, Genetics and Evolution 30: 296- 307 (2015)
Abstract© 2014 Elsevier B.V. Recombination is a pervasive process generating diversity in most viruses. It joins variants that arise independently within the same molecule, creating new opportunities for viruses to overcome selective pressures and to adapt to new environments and hosts. Consequently, the analysis of viral recombination attracts the interest of clinicians, epidemiologists, molecular biologists and evolutionary biologists. In this review we present an overview of three major areas related to viral recombination: (i) the molecular mechanisms that underlie recombination in model viruses, including DNA-viruses (Herpesvirus) and RNA-viruses (Human Influenza Virus and Human Immunodeficiency Virus), (ii) the analytical procedures to detect recombination in viral sequences and to determine the recombination breakpoints, along with the conceptual and methodological tools currently used and a brief overview of the impact of new sequencing technologies on the detection of recombination, and (iii) the major areas in the evolutionary analysis of viral populations on which recombination has an impact. These include the evaluation of selective pressures acting on viral populations, the application of evolutionary reconstructions in the characterization of centralized genes for vaccine design, and the evaluation of linkage disequilibrium and population structure.
URIhttp://hdl.handle.net/10261/140233
DOI10.1016/j.meegid.2014.12.022
Identifiersdoi: 10.1016/j.meegid.2014.12.022
issn: 1567-7257
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