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Open Access item Association study of functional genetic variants of innate immunity related genes in celiac disease

Authors:Rueda, B.
Zhernakova, A.
López-Nevot, M. A.
Martín, J.
Koeleman, B. P.
Issue Date:3-Aug-2005
Publisher:BioMed Central
Citation:BMC Medical Genetics 2005, 6:29
Abstract:[Background] Recent evidence suggest that the innate immune system is implicated in the early events of celiac disease (CD) pathogenesis. In this work for the first time we have assessed the relevance of different proinflammatory mediators typically related to innate immunity in CD predisposition.
[Methods] We performed a familial study in which 105 celiac families characterized by the presence of an affected child with CD were genotyped for functional polymorphisms located at regulatory regions of IL-1α, IL-1β, IL-1RN, IL-18, RANTES and MCP-1 genes. Familial data was analysed with a transmission disequilibrium test (TDT) that revealed no statistically significant differences in the transmission pattern of the different genetic markers considered.
[Results] The TDT analysis for IL-1α, IL-1β, IL-1RN, IL-18, and MCP-1 genes genetic variants did not reveal biased transmission to the affected offspring. Only a borderline association of RANTES promoter genetic variants with CD predisposition was observed.
[Conclusion] Our results suggest that the analysed polymorphisms of IL-1α, IL-1β, IL-1RN, IL-18, RANTES and MCP-1 genes do not seem to play a major role in CD genetic predisposition in our population.
Description:This article is available from: http://www.biomedcentral.com/1471-2350/6/29
URI:http://hdl.handle.net/10261/1401
ISSN:1471-2350
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Appears in Collections:(IPBLN) Artículos

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