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dc.contributor.authorCanales, Mario-
dc.contributor.authorAlmazán, Consuelo-
dc.contributor.authorNaranjo, María Victoria-
dc.contributor.authorJongejan, Frans-
dc.contributor.authorFuente, José de la-
dc.date.accessioned2009-06-26T09:29:51Z-
dc.date.available2009-06-26T09:29:51Z-
dc.date.issued2009-03-31-
dc.identifier.citationBMC Biotechnology 2009, 9:29en_US
dc.identifier.issn1472-6750-
dc.identifier.urihttp://hdl.handle.net/10261/14007-
dc.description8 pages,2 figures and 2 tablesen_US
dc.description.abstract[Background] The cattle ticks, Boophilus spp., affect cattle production in tropical and subtropical regions of the world. Tick vaccines constitute a cost-effective and environmentally friendly alternative to tick control. The recombinant B. microplus Bm86 protective antigen has been shown to protect cattle against tick infestations. Recently, the gene coding for B. annulatus Bm86 ortholog, Ba86, was cloned and the recombinant protein was secreted and purified from the yeast Pichia pastoris.en_US
dc.description.abstract[Results] Recombinant Ba86 (Israel strain) was used to immunize cattle to test its efficacy for the control of B. annulatus (Mercedes, Texas, USA strain) and B. microplus (Susceptible, Mexico strain) infestations. Bm86 (Gavac and Mozambique strain) and adjuvant/saline were used as positive and negative controls, respectively. Vaccination with Ba86 reduced tick infestations (71% and 40%), weight (8% and 15%), oviposition (22% and 5%) and egg fertility (25% and 50%) for B. annulatus and B. microplus, respectively. The efficacy of both Ba86 and Bm86 was higher for B. annulatus than for B. microplus. The efficacy of Ba86 was higher for B. annulatus (83.0%) than for B. microplus (71.5%). The efficacy of Bm86 (Gavac; 85.2%) but not Bm86 (Mozambique strain; 70.4%) was higher than that of Ba86 (71.5%) on B. microplus. However, the efficacy of Bm86 (both Gavac and Mozambique strain; 99.6%) was higher than that of Ba86 (83.0%) on B. annulatus.en_US
dc.description.abstract[Conclusion] These experiments showed the efficacy of recombinant Ba86 for the control of B. annulatus and B. microplus infestations in cattle and suggested that physiological differences between B. microplus and B. annulatus and those encoded in the sequence of Bm86 orthologs may be responsible for the differences in susceptibility of these tick species to Bm86 vaccines.en_US
dc.description.sponsorshipThis work was supported by the Wellcome Trust under the Animal Health in the Developing World initiative through project 0757990 entitled "Adapting recombinant anti-tick vaccines to livestock in Africa" and the Consejería de Educación y Ciencia, JCCM, Spain (project PAI06-0046-5285) and was facilitated through the Integrated Consortium on Ticks and Tick-borne Diseases (ICTTD-3), financed by the International Cooperation Program of the European Union, coordination action project No. 510561.en_US
dc.format.extent264574 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofPublisher's version-
dc.rightsopenAccessen_US
dc.subjectBoophilus annulatusen_US
dc.subjectB. microplusen_US
dc.subjectBm86en_US
dc.subjectBa86en_US
dc.subjectRecombinanten_US
dc.subjectVaccinationen_US
dc.titleVaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestationsen_US
dc.typeartículoen_US
dc.identifier.doi10.1186/1472-6750-9-29-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1186/1472-6750-9-29en_US
dc.identifier.pmid19335900-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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