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Título: | Novel connection between newborn granule neurons and the hippocampal CA2 field |
Autor: | Llorens-Martín, María CSIC ORCID ; Jurado-Arjona, Jerónimo CSIC; Ávila, Jesús CSIC ORCID ; Hernández Pérez, Félix CSIC ORCID | Palabras clave: | Retrovirus CA2 Adult neurogenesis Mossy fiber terminal Granule neurons |
Fecha de publicación: | 1-nov-2014 | Editor: | Academic Press | Citación: | Experimental Neurology 263: 285- 292 (2015) | Resumen: | © 2014 Elsevier Inc. Newborn neurons are continuously added to the hippocampal dentate gyrus (DG) throughout life. Mature and immature granule neurons are believed to send their axonal projections exclusively to the hippocampal CA3 field. However, recent data point to an alternative trisynaptic circuit, involving a direct axonal projection from mature granule neurons to the CA2 field. Whether this circuit takes place only in mature granule neurons or, on the contrary, whether immature granule neurons also contribute to this novel connection is unknown. We used various retroviral vectors to show that immature granule neurons send axonal processes to and establish synaptic contacts with CA2 pyramidal neurons and that axonal growth follows a similar time course to that described for CA3 innervation. In addition, we provide experimental evidence demonstrating that the pathway connecting newborn granule neurons and the CA2 field can be modulated by physiological and deleterious stimuli. | URI: | http://hdl.handle.net/10261/139949 | DOI: | 10.1016/j.expneurol.2014.10.021 | Identificadores: | doi: 10.1016/j.expneurol.2014.10.021 issn: 1090-2430 |
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Avila J Novel connection.pdf | 2,05 MB | Adobe PDF | Visualizar/Abrir |
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