English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/1398
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 22 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

ACRATA: a novel electron transfer domain associated to apoptosis and cancer

Autor Sánchez-Pulido, Luis; Rojas, A. M. ; Valencia, Alfonso; Martínez-Alonso, Carlos; Andrade, Miguel A.
Fecha de publicación 19-dic-2004
EditorBioMed Central
Citación BMC Cancer 498: 98 (2004)
Resumen[Background] Recently, several members of a vertebrate protein family containing a six trans-membrane (6TM) domain and involved in apoptosis and cancer (e.g. STEAP, STAMP1, TSAP6), have been identified in Golgi and cytoplasmic membranes. The exact function of these proteins remains unknown.
[Methods] We related this 6TM domain to distant protein families using intermediate sequences and methods of iterative profile sequence similarity search.
[Results] Here we show for the first time that this 6TM domain is homolog to the 6TM heme binding domain of both the NADPH oxidase (Nox) family and the YedZ family of bacterial oxidoreductases.
[Conclusions] This finding gives novel insights about the existence of a previously undetected electron transfer system involved in apoptosis and cancer, and suggests further steps in the experimental characterization of these evolutionarily related families.
Versión del editorhttp://dx.doi.org/10.1186/1471-2407-4-98
URI http://hdl.handle.net/10261/1398
DOI10.1186/1471-2407-4-98
ISSN1471-2407
Aparece en las colecciones: (CNB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
1471-2407-4-98.pdf341,68 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.