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Infrared Fluorescent Imaging as a Potent Tool for In Vitro, Ex Vivo and In Vivo Models of Visceral Leishmaniasis

AuthorsCalvo-Álvarez, Estefanía; Stamatakis, Konstantinos ; Punzón, Carmen ; Álvarez-Velilla, Raquel; Tejería, Ana; Escudero-Martínez, José Miguel; Pérez-Pertejo, Yolanda; Fresno, Manuel ; Balaña-Fouce, Rafael; Reguera, Rosa M.
Issue Date31-Mar-2015
PublisherPublic Library of Science
CitationPLoS Neglected Tropical Diseases 9: e00036666 (2015)
AbstractVisceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the parenteral administration route of most of them, are significant concerns of the current leishmanicidal medicines. New drugs are desperately needed to treat VL and phenotype-based High Throughput Screenings (HTS) appear to be suitable to achieve this goal in the coming years.
Identifiersdoi: 10.1371/journal.pntd.0003666
issn: 1935-2735
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