Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/139256
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Expanding the Iroquois genes repertoire: a nontranscriptional function in cell cycle progression |
Autor: | Barrios, Natalia CSIC; Campuzano, Sonsoles CSIC ORCID | Palabras clave: | tumor suppressor genes Drosophila Imaginal discs Iroquois genes Cell proliferation |
Fecha de publicación: | 13-jun-2016 | Editor: | Landes Bioscience | Citación: | Fly 9: 126- 131 (2015) | Resumen: | Drosophila Iroquois (Iro) proteins are components of the TALE homeodomain family of transcriptional regulators. They play key roles in territorial specification and pattern formation. A recent study has disclosed a novel developmental function of the Iro proteins. In the eye and wing imaginal discs, they can regulate the size of the territories that they specify. They do so by cell–autonomously controlling cell cycle progression. Indeed, Iro proteins down-regulate the activity of the CyclinE/Cdk2 complex by a transcription-independent mechanism. This novel function is executed mainly through 2 evolutionarily conserved domains of the Iro proteins: the Cyclin Binding Domain and the IRO-box, which mediate their binding to CyclinEcontaining protein complexes. Here we discuss the functional implications of the control of the cell cycle by Iro proteins for development and oncogenesis. | URI: | http://hdl.handle.net/10261/139256 | DOI: | 10.1080/19336934.2016.1139654 | Identificadores: | doi: 10.1080/19336934.2016.1139654 issn: 1933-6934 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
CampuzanoS_ExpandingThe IroquoisGenesREPERTOIRE.pdf | 940,22 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
2
checked on 24-mar-2024
SCOPUSTM
Citations
4
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 29-feb-2024
Page view(s)
177
checked on 17-abr-2024
Download(s)
246
checked on 17-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.