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dc.contributor.authorPinazo, María Jesúses_ES
dc.contributor.authorThomas, María del Carmenes_ES
dc.contributor.authorBustamante, Juanes_ES
dc.contributor.authorAlmeida, Igor C.es_ES
dc.contributor.authorLópez López, Manuel Carloses_ES
dc.contributor.authorGascón, Joaquimes_ES
dc.date.accessioned2016-09-20T08:27:08Z-
dc.date.available2016-09-20T08:27:08Z-
dc.date.issued2015-05-
dc.identifier.citationMemórias do Instituto Oswaldo Cruzes_ES
dc.identifier.issn0074-0276-
dc.identifier.urihttp://hdl.handle.net/10261/137011-
dc.description.abstractThe definition of a biomarker provided by the World Health Organization is any substance, structure, or process that can be measured in the body, or its products and influence, or predict the incidence or outcome of disease. Currently, the lack of prognosis and progression markers for chronic Chagas disease has posed limitations for testing new drugs to treat this neglected disease. Several molecules and techniques to detect biomarkers in Trypanosoma cruzi-infected patients have been proposed to assess whether specific treatment with benznidazole or nifurtimox is effective. Isolated proteins or protein groups from different T. cruzi stages and parasite-derived glycoproteins and synthetic neoglycoconjugates have been demonstrated to be useful for this purpose, as have nucleic acid amplification techniques. The amplification of T. cruzi DNA using the real-time polymerase chain reaction method is the leading test for assessing responses to treatment in a short period of time. Biochemical biomarkers have been tested early after specific treatment. Cytokines and surface markers represent promising molecules for the characterisation of host cellular responses, but need to be further assessed.es_ES
dc.description.sponsorshipRICET RD12/0018/0010. RICET RD12/0018/0021. AGAUR 2014SGR26. Plan Nacional de I+D+I SAF2012-35777. Plan Nacional de I+D+I SAF2013-48527-R. NIMHD/NIH 2G12MD007592. Financial support: CRESIB and IPBLN research members were partially supported by the RICET (RD12/0018/0010, RD12/0018/0021), M-JP and JG received research funds from AGAUR (2014SGR26) and Fundación Mundo Sano, M-CT and M-CL were supported by Plan Nacional de I+D+I (MINECO-Spain) (SAF2012-35777, SAF2013-48527-R and FEDER), ICA was partially supported by NIMHD/NIH (2G12MD007592). Financial support: CRESIB and IPBLN research members were partially supported by the RICET (RD12/0018/0010, RD12/0018/0021), M-JP and JG received research funds from AGAUR (2014SGR26) and Fundación Mundo Sano, M-CT and M-CL were supported by Plan Nacional de I+D+I (MINECO-Spain) (SAF2012-35777, SAF2013-48527-R and FEDER), ICA was partially supported by NIMHD/NIH (2G12MD007592).es_ES
dc.language.isoenges_ES
dc.publisherInstituto Oswaldo Cruzes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectbiological markeres_ES
dc.subjectChagas diseasees_ES
dc.subjectTrypanosoma cruzies_ES
dc.subjecttherapeutic responsees_ES
dc.subjectparasite markeres_ES
dc.subjecthost markerses_ES
dc.titleBiomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectiveses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1590/0074-02760140435-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://memorias.ioc.fiocruz.br/issues/past-issues/item/3709-0435_biomarkers-of-therapeutic-responses-in-chronic-chagas-disease-state-of-the-art-and-future-perspectiveses_ES
dc.identifier.e-issn1678-8060-
dc.rights.licensehttp://memorias.ioc.fiocruz.br/subscriptiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
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