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Title

Contribution of glutathione to the control of cellular redox homeostasis under toxic metal and metalloid stress

AuthorsHernández, Luis E.; Sobrino-Plata, Juan; Montero-Palmero, M. Belén; Carrasco-Gil, Sandra ; Flores-Cáceres, M. Laura; Ortega-Villasante, Cristina; Escobar, Carolina
Keywordsdetoxification
glutathione
hormones
metal(loid)s
phytochelatins
phytotoxicity
redox homeostasis
sulphur
Issue Date2015
PublisherOxford University Press
CitationHernández LE, Sobrino-Plata J, Montero-Palmero MB, Carrasco-Gil S, Flores-Cáceres ML, Ortega-Villasante C, Escobar C. Contribution of glutathione to the control of cellular redox homeostasis under toxic metal and metalloid stress. Journal of Experimental Botany 66 (10): 2901-2911 (2015)
AbstractThe accumulation of toxic metals and metalloids, such as cadmium (Cd), mercury (Hg), or arsenic (As), as a consequence of various anthropogenic activities, poses a serious threat to the environment and human health. The ability of plants to take up mineral nutrients from the soil can be exploited to develop phytoremediation technologies able to alleviate the negative impact of toxic elements in terrestrial ecosystems. However, we must select plant species or populations capable of tolerating exposure to hazardous elements. The tolerance of plant cells to toxic elements is highly dependent on glutathione (GSH) metabolism. GSH is a biothiol tripeptide that plays a fundamental dual role: first, as an antioxidant to mitigate the redox imbalance caused by toxic metal(loid) accumulation, and second as a precursor of phytochelatins (PCs), ligand peptides that limit the free ion cellular concentration of those pollutants. The sulphur assimilation pathway, synthesis of GSH, and production of PCs are tightly regulated in order to alleviate the phytotoxicity of different hazardous elements, which might induce specific stress signatures. This review provides an update on mechanisms of tolerance that depend on biothiols in plant cells exposed to toxic elements, with a particular emphasis on the Hg-triggered responses, and considering the contribution of hormones to their regulation.
Description11 Pags.- 3 Figs.
Publisher version (URL)http://dx.doi.org/10.1093/jxb/erv063
URIhttp://hdl.handle.net/10261/136903
DOI10.1093/jxb/erv063
ISSN0022-0957
E-ISSN1460-2431
Appears in Collections:(EEAD) Artículos
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