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Trehalose-based Janus cyclooligosaccharides: the ‘‘Click’’ synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles

AuthorsJiménez Blanco, José L.; Ortega-Caballero, Fernando; Junquera, Elena; Mendicuti, Francisco; Tros de llarduya, Conchita; Ortiz-Mellet, Carmen; García-Fernández, José Manuel
Issue Date2016
PublisherRoyal Society of Chemistry (UK)
CitationChemical Communications 52(66): 10117-10120 (2016)
AbstractThe convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been implemented; the strategy allows access to macrocyclic derivatives with seggregated cationic and lipophilic domains that in the presence of DNA undergo pH-dependent self-assembly into lamellar superstructures, as established by electrochemical, structural (SAXS), microscopical (TEM) and computational techniques, that mediate transfection in vitro and in vivo.
DescriptionThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.-- et al.
Publisher version (URL)http://dx.doi.org/10.1039/C6CC04791B
Appears in Collections:(IIQ) Artículos
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