Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/135835
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2 |
Autor: | Pandiella, Atanasio CSIC ORCID CVN ; Morís, Francisco; Ocaña, Alberto; Núñez, Luz-Elena; Montero, Juan Carlos CSIC ORCID | Palabras clave: | Mithralogs Cell cycle Triple negative breast cancer EC-8042 |
Fecha de publicación: | 2015 | Editor: | Impact Journals | Citación: | Oncotarget 6(32): 32856-32867 (2015) | Resumen: | Triple negative breast cancer (TNBC) is an aggressive form of breast cancer. Despite response to chemotherapy, relapses are frequent and resistance to available treatments is often observed in the metastatic setting. Therefore, identification of new therapeutic strategies is required. Here we have investigated the effect of the mithramycin analog EC-8042 (demycarosil-3D-β-D-digitoxosyl mithramycin SK) on TNBC. The drug caused a dose-dependent inhibition of proliferation of a set of TNBC cell lines in vitro, and decreased tumor growth in mice xenografted with TNBC cells. Mechanistically, EC-8042 caused an arrest in the G2 phase of the cell cycle, coincident with an increase in pCDK1 and Wee1 levels in cells treated with the drug. In addition, prolonged treatment with the drug also causes apoptosis, mainly through caspaseindependent routes. Importantly, EC-8042 synergized with drugs commonly used in the therapy of TNBC in vitro, and potentiated the antitumoral effect of docetaxel in vivo. Together, these data suggest that the mithralog EC-8042 exerts an antitumoral action on TNBC cells and reinforces the action of standard of care drugs used in the therapy of this disease. These characteristics, together with a better toxicology profile of EC-8042 with respect to mithramycin, open the possibility of its clinical evaluation. | Descripción: | This is an open-access article distributed under the terms of the Creative Commons Attribution License. | Versión del editor: | http://dx.doi.org/10.18632/oncotarget.5942 | URI: | http://hdl.handle.net/10261/135835 | DOI: | 10.18632/oncotarget.5942 | Identificadores: | doi: 10.18632/oncotarget.5942 e-issn: 1949-2553 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
arrest in G2.pdf | 3,04 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 10-abr-2024
SCOPUSTM
Citations
18
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 27-feb-2024
Page view(s)
317
checked on 24-abr-2024
Download(s)
250
checked on 24-abr-2024