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Title

The predominant myeloma clone at diagnosis, CDR3 defined, is constantly detectable across all stages of disease evolution

AuthorsPuig, Noemi; Sarasquete, María Eugenia; Balanzategui, Ana; Alcoceba, Miguel; Chillón, M. del Carmen; Sebastián, Elena; Gutiérrez, Norma Carmen; San Miguel, Jesús F. ; García-Sanz, Ramón
Issue Date2015
PublisherNature Publishing Group
CitationLeukemia 29(6): 1435-1437 (2015)
AbstractMultiple myeloma (MM) pathogenesis has been explained for many years by the cancer biology dogma introduced in 1976 by Peter Nowell:1 first, a single plasma cell would be immortalized by an error in the immunoglobulin genes rearrangement process; then, a progressive stepwise acquisition of somatic cell mutations would induce a sequential selection, leading to domination by the fittest clone.2 In line with this idea of ‘myeloma stability’, single-nucleotide polymorphism arrays studies in diagnostic-relapse paired samples have revealed the presence of common clonal characteristics.3 Biologically, the M-protein remains usually constant across MM evolution, to the point that it is conventionally used to monitor treatment response and disease progress. Further, the variable domain of the rearranged immunoglobulin heavy-chain genes (or CDR3 region) has been used as a patient-specific myeloma fingerprint in minimal residual disease (MRD) studies.
URIhttp://hdl.handle.net/10261/135768
DOI10.1038/leu.2015.7
Identifiersdoi: 10.1038/leu.2015.7
e-issn: 1476-5551
issn: 0887-6924
Appears in Collections:(IBMCC) Artículos
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