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Comprehensive analysis of the translation of immunoreactions into nanomechanical microcantilever bending

AuthorsKosaka, Priscila M. ; Tamayo de Miguel, Francisco Javier ; Grazú, Valeria; Ruz Martínez, José Jaime ; Puertas, Sara; Polo, Ester; Fuente, Jesús M. de la; Calleja, Montserrat
KeywordsLabel-free biosensor
Surface stress
Issue DateJun-2012
Citation9th Nanomechanical sensing workshop (2012)
AbstractAs medicine progresses toward diagnostics based on molecular markers, the necessity for a rapid, sensitive and highthroughput method for the detection of biomolecules rises. The need of label-free techniques with high level of sensitivity has increased the number of label-free techniques based on nanoscience and nanotechnology such as micro/nanocantilever sensors. We have studied the surface stress response of 841 microcantilevers to antibody immobilizatian, blocking with boüne serum albumin or polyethylene-glycol, control experiments and antigen recognition. This study shows a high variability in the surface stress variation after each step. However, a correlation is found between the antigen recognition-induced surface stress and the antibodv and blocking surface stresses.
DescriptionComunicación presentada en el 9th Nanomechanical sensing workshop, celebrado en Bombay del 6 al 8 de junio de 2012.
Appears in Collections:(IMN-CNM) Comunicaciones congresos
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