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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/134839
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dc.contributor.authorPastor-Idoate, Salvador-
dc.contributor.authorRodríguez-Hernández, Irene-
dc.contributor.authorGonzález-Sarmiento, Rogelio-
dc.contributor.authorPastor, José Carlos-
dc.date.accessioned2016-07-15T12:10:37Z-
dc.date.available2016-07-15T12:10:37Z-
dc.date.issued2015-
dc.identifierdoi: 10.1111/aos.12718-
dc.identifiere-issn: 1755-3768-
dc.identifier.citationActa Ophthalmologica 93(7): e541-e549 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/134839-
dc.descriptionGenetics on PVR Study Group: et al.-
dc.descriptionMeeting Presentation: EVER Annual Meeting, Nice, October 2014 as a poster and rapid paper.-
dc.description.abstract[Purpose]: To compare the distribution of BCL-2 -938C>A (rs2279115) and BAX -248G>A (rs4645878) genotypes among European subjects undergoing rhegmatogenous retinal detachment (RRD) surgery in relation to the further development of proliferative vitreoretinopathy (PVR). [Methods]: A case-control gene association study, as a part of Retina 4 project, was designed. rs2279115 and rs4645878 polymorphisms were analysed in 555 samples from patients with RRD (134 with PVR secondary to surgery). Proportions of genotypes and AA homozygous groups of BCL-2 and BAX polymorphisms between subsamples were analysed in two phases. Genotypic and allelic frequencies were compared in global sample and in subsamples. [Results]: BAX: Differences were observed in the genotype frequencies and in AA carriers between controls and cases in the global series. The odds ratio (OR) of A carriers in the global sample was 1.7 (95% CI: 1.23-2.51). Proportions of genotypes in Spain + Portugal were significant different. The OR of A carriers from Spain and Portugal was 1.8 (95% CI: 1.11-2.95). BCL-2: No significant differences were observed in genotype frequencies. However, proportions of genotypes in Spain + Portugal were significant. A protective effect (OR: 0.6 95% CI: 0.43-0.96) was found in A carriers from Spain and Portugal. [Conclusions]: Results suggest that A allele of rs4645878 could be a biomarker of high risk of developing PVR in patients undergoing RD surgery. The possible role of BCL-2 (inhibitor of necroptosis pathway) as a possible new target in PVR prophylaxis should be investigated.-
dc.description.sponsorshipThe authors acknowledge (a proportion of their) financial support from the Department of Health through the award made by the National Institute for Health Research to Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology for a Specialist Biomedical Research Centre for Ophthalmology. The views expressed in this publication are those of the authors and not necessarily those of the Department of Health. This research was partially funded by SAF 2007-66394, FIS PI10/00219 and Group of Excellence Grant (GR15) from Junta de Castilla y León. The funding organization had no role in the design or conduct of this research.-
dc.publisherJohn Wiley & Sons-
dc.rightsclosedAccess-
dc.subjectNecroptosis-
dc.subjectProliferative vitreoretinopathy-
dc.subjectRetinal detachment-
dc.subjectBax-
dc.subjectBCL-2-
dc.subjectApoptosis-
dc.titleBAX and BCL-2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project-
dc.typeartículo-
dc.identifier.doi10.1111/aos.12718-
dc.date.updated2016-07-15T12:10:38Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderNational Institutes of Health (US)-
dc.contributor.funderMoorfields Eye Hospital (UK)-
dc.contributor.funderUniversity of California-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderJunta de Castilla y León-
dc.relation.csicSí-
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100005595es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100014180es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeartículo-
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