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Multiparameter flow cytometry for staging of solitary bone plasmacytoma: New criteria for risk of progression to myeloma

AuthorsPaiva, Bruno; Vidriales, Maria Belén; Colado, Enrique; Caballero-Velázquez, Teresa; García de Coca, Alfonso; García-Sanz, Ramón; Ocio, Enrique M. ; Mateos, Maria Victoria; San Miguel, Jesús F.
Issue Date2014
PublisherAmerican Society of Hematology
CitationBlood 124(8): 1300-1303 (2014)
AbstractSolitary plasmacytoma represents a heterogeneous group of patients; approximately half develop multiple myeloma (MM) in 2 or 3 years,whereas others remain disease-free at 10 years. By definition, these patients do not have morphologic bone marrow (BM) plasma cell (PC) infiltration. Here, we investigated whether sensitive BM evaluation of patients withsolitaryboneplasmacytoma(SBP; n = 35) andextramedullary plasmacytoma (EMP; n = 29) through multiparameter flow cytometry (MFC) would unravel the presence of clonal PCs in otherwise disease-free BM, and whether BMclonality predicted higher risk of progression. BMclonal PCs were detected in 17 of 35 SBP (49%) and 11 of 29 EMP (38%) patients. Seventy-one percent of flow-positive vs only 8% of flow-negative SBP patients evolved to MM (median time to progression of 26 months vs not reached; hazard ratio, 17.4; P < .001). No significant differences were observed among EMP cases. Our results highlight the importance of MFC for sensitive BM evaluation of SBP patients, to predict risk of developing treatment-requiring MM and to plan disease monitoring.
Identifiersdoi: 10.1182/blood-2014-04-567909
e-issn: 1528-0020
issn: 0006-4971
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