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http://hdl.handle.net/10261/134668
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Orfao, Alberto | - |
dc.contributor.author | Quijano Gómez, S. M. | - |
dc.date.accessioned | 2016-07-11T12:10:59Z | - |
dc.date.available | 2016-07-11T12:10:59Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.1111/cei.12337 | - |
dc.identifier | e-issn: 1365-2249 | - |
dc.identifier | issn: 0009-9104 | - |
dc.identifier.citation | Clinical and Experimental Immunology 177(1): 320-332 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/134668 | - |
dc.description.abstract | Epstein-Barr virus (EBV) is present in 95% of the world's adult population. The immune response participates in immune vigilance and persistent infection control, and this condition is maintained by both a good quality (functionality) and quantity of specific T cells throughout life. In the present study, we evaluated EBV-specific CD4+ and CD8+ T lymphocyte responses in seropositive healthy individuals younger and older than 50 years of age. The assessment comprised the frequency, phenotype, functionality and clonotypic distribution of T lymphocytes. We found that in both age groups a similar EBV-specific T cell response was found, with overlapping numbers of tumour necrosis factor (TNF)-α+ T lymphocytes (CD4+ and CD8+) within the memory and effector cell compartments, in addition to monofunctional and multi-functional T cells producing interleukin (IL)-2 and/or interferon (IFN)-γ. However, individuals aged more than 50 years showed significantly higher frequencies of IL-2-producing CD4+ T lymphocytes in association with greater production of soluble IFN-γ, TNF-α and IL-6 than subjects younger than 50 years. A polyclonal T cell receptor (TCR)-variable beta region (Vβ) repertoire exists in both age groups under basal conditions and in response to EBV; the major TCR families found in TNF-α+/CD4+ T lymphocytes were Vβ1, Vβ2, Vβ17 and Vβ22 in both age groups, and the major TCR family in TNF-α+/CD8+ T cells was Vβ13·1 for individuals younger than 50 years and Vβ9 for individuals aged more than 50 years. Our findings suggest that the EBV-specific T cell response (using a polyclonal stimulation model) is distributed throughout several T cell differentiation compartments in an age-independent manner and includes both monofunctional and multi-functional T lymphocytes. | - |
dc.description.sponsorship | This study was supported by the following grants: ID 4149 and ID 3128 from the Pontificia Universidad Javeriana Bogotá, Colombia. | - |
dc.publisher | John Wiley & Sons | - |
dc.rights | closedAccess | - |
dc.subject | Multi-functional T lymphocytes | - |
dc.subject | TCR-Vβ repertoire | - |
dc.subject | Soluble cytokines | - |
dc.subject | Flow cytometry | - |
dc.subject | EBV-specific memory and effector T lymphocytes | - |
dc.title | Age-associated Epstein-Barr virus-specific T cell responses in seropositive healthy adults | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/cei.12337 | - |
dc.date.updated | 2016-07-11T12:11:00Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Pontificia Universidad Javeriana | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100009543 | es_ES |
dc.identifier.pmid | 24666437 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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