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Closed Access item Efficient and selective removal of methoxy protecting groups in carbohydrates

Authors:Boto, Alicia
Hernández, Dácil
Hernández, Rosendo
Suárez, Ernesto
Issue Date:21-Sep-2004
Publisher:American Chemical Society
Citation:Organic Letters 6(21): 3785-3788 (2004)
Abstract:[Reaction: see text] The selective removal from carbohydrate substrates of methoxy protecting groups next to hydroxy groups is reported. On treatment with PhI(OAc)(2)-I(2), the methoxy group is transformed into an easily removable acetal. The mild conditions of this methodology are compatible with many functional groups, and good to excellent yields are usually achieved.
Description:4 pages, 1 table, 4 schemes.-- PMID: 15469349 [PubMed].-- Printed version published Oct 14, 2004.
Supporting information available: Synthesis of substrate 12 and General Procedure for the one-pot protecting group transformation-hydrolysis. 1H and 13C NMR spectra and spectroscopic data for several compounds.-- Available at: http://pubs.acs.org/doi/suppl/10.1021/ol048439%2B
Publisher version (URL):http://dx.doi.org/10.1021/ol048439+
URI:http://hdl.handle.net/10261/13461
ISSN:1523-7060
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Appears in Collections:(IPNA) Artículos

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