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http://hdl.handle.net/10261/134567
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Molinari, Aurora | - |
dc.contributor.author | Castro, M. Ángeles | - |
dc.contributor.author | Mollinedo, Faustino | - |
dc.date.accessioned | 2016-07-07T09:50:30Z | - |
dc.date.available | 2016-07-07T09:50:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier | doi: 10.1002/ardp.201300137 | - |
dc.identifier | issn: 0365-6233 | - |
dc.identifier | e-issn: 1521-4184 | - |
dc.identifier.citation | Archiv der Pharmazie 346(12): 882-890 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/134567 | - |
dc.description.abstract | We report on the synthesis of two series of 1,4-naphthohydroquinone derivatives conjugated with amino acids (Gly, Ala, Phe, and Glu) and with substituted purines linked by an aliphatic chain. The compounds were obtained through Diels-Alder cycloaddition between myrcene and 1,4-benzoquinone and evaluated in vitro for their cytotoxicity (GI50) against cultured human cancer cells of A-549 lung carcinoma, HT-29 colon adenocarcinoma, and MCF-7 breast carcinoma. The GI50 values found for some hydroquinone-amino acid and hydroquinone-purine hybrids against MCF-7 are in an activity range comparable to that of the reference drug doxorubicin. | - |
dc.description.sponsorship | Funded by: “Comisión Nacional de Investigación Científica y Tecnológica”, CONICYT (Project FONDECYT 1060447), “Dirección de Investigación de la Vicerrectoría de Investigación y Estudios Avanzados de la Pontificia Universidad Católica de Valparaíso”, Chile (Project DII 125.796/2006) and “Junta de Castilla y León”, Spain (SA028A10-2) and European Commission | - |
dc.publisher | Wiley-VCH | - |
dc.rights | closedAccess | - |
dc.subject | Antineoplastic | - |
dc.subject | Hydroquinone–purine | - |
dc.subject | Hydroquinone–amino acid | - |
dc.subject | Hybrids | - |
dc.subject | Cytotoxicity | - |
dc.title | Synthesis and evaluation as antitumor agents of 1,4-naphthohydroquinone derivatives conjugated with amino acids and purines | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1002/ardp.201300137 | - |
dc.date.updated | 2016-07-07T09:50:30Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Comisión Nacional de Investigación Científica y Tecnológica (Chile) | - |
dc.contributor.funder | Junta de Castilla y León | - |
dc.contributor.funder | Pontificia Universidad Católica de Valparaíso | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002848 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007776 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100014180 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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