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Título: | Synthesis and evaluation as antitumor agents of 1,4-naphthohydroquinone derivatives conjugated with amino acids and purines |
Autor: | Molinari, Aurora; Castro, M. Ángeles CSIC ORCID; Mollinedo, Faustino CSIC ORCID | Palabras clave: | Antineoplastic Hydroquinone–purine Hydroquinone–amino acid Hybrids Cytotoxicity |
Fecha de publicación: | 2013 | Editor: | Wiley-VCH | Citación: | Archiv der Pharmazie 346(12): 882-890 (2013) | Resumen: | We report on the synthesis of two series of 1,4-naphthohydroquinone derivatives conjugated with amino acids (Gly, Ala, Phe, and Glu) and with substituted purines linked by an aliphatic chain. The compounds were obtained through Diels-Alder cycloaddition between myrcene and 1,4-benzoquinone and evaluated in vitro for their cytotoxicity (GI50) against cultured human cancer cells of A-549 lung carcinoma, HT-29 colon adenocarcinoma, and MCF-7 breast carcinoma. The GI50 values found for some hydroquinone-amino acid and hydroquinone-purine hybrids against MCF-7 are in an activity range comparable to that of the reference drug doxorubicin. | URI: | http://hdl.handle.net/10261/134567 | DOI: | 10.1002/ardp.201300137 | Identificadores: | doi: 10.1002/ardp.201300137 issn: 0365-6233 e-issn: 1521-4184 |
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