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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Briones, Carlos | - |
dc.contributor.author | Stich, Michael | - |
dc.contributor.author | Manrubia Cuevas, Susanna | - |
dc.date.accessioned | 2009-06-03T12:17:38Z | - |
dc.date.available | 2009-06-03T12:17:38Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | RNA 15(5): 743-749 (2009) | en_US |
dc.identifier.issn | 1355-8382 | - |
dc.identifier.uri | http://hdl.handle.net/10261/13449 | - |
dc.description | 7 pages.-- PMID: 19318464 [PubMed].-- PMCID: PMC2673073 [Available Open Access on 2009/11/01]. | en_US |
dc.description.abstract | A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered. | en_US |
dc.format.extent | 35185 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Cambridge University Press | en_US |
dc.rights | closedAccess | en_US |
dc.subject | RNA folding | en_US |
dc.subject | Structural motif | en_US |
dc.subject | Modular evolution | en_US |
dc.subject | RNA ligation | en_US |
dc.subject | Hairpin ribozyme | en_US |
dc.subject | RNA polymerase | en_US |
dc.title | The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1261/rna.1488609 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1261/rna.1488609 | en_US |
dc.identifier.e-issn | 1469-9001 | - |
dc.identifier.pmid | 19318464 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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