English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/13449
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers

AuthorsBriones, Carlos ; Stich, Michael ; Manrubia Cuevas, Susanna
KeywordsRNA folding
Structural motif
Modular evolution
RNA ligation
Hairpin ribozyme
RNA polymerase
Issue DateMay-2009
PublisherCambridge University Press
CitationRNA 15(5): 743-749 (2009)
AbstractA main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered.
Description7 pages.-- PMID: 19318464 [PubMed].-- PMCID: PMC2673073 [Available Open Access on 2009/11/01].
Publisher version (URL)http://dx.doi.org/10.1261/rna.1488609
Appears in Collections:(CAB) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.