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Title

The first European interdisciplinary Ewing sarcoma research summit

AuthorsKovar, Heinrich; Alonso, Javier; Álava, Enrique de ; Herrero-Martín, David
KeywordsSarcomagenesis
Prognosis
Drug screen
Biomarkers
Epigenetics
Genomics
Animal models
Ewing sarcoma
Issue Date2012
PublisherFrontiers Media
CitationFrontiers in Oncology 2: 54 (2012)
AbstractThe European Network for Cancer Research in Children and Adolescents (ENCCA) provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA objectives is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options, since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma (ES), where long term survival rates are still below 20%. Despite significant progress in our understanding of ES biology, clinical translation of promising laboratory results has not yet taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and five North American opinion leaders in December 2011 to exchange thoughts and discuss the state of the art in ES research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.
DescriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License.-- et al.
Publisher version (URL)http://dx.doi.org/10.3389/fonc.2012.00054
URIhttp://hdl.handle.net/10261/134304
DOI10.3389/fonc.2012.00054
Identifiersdoi: 10.3389/fonc.2012.00054
e-issn: 2234-943X
Appears in Collections:(IBMCC) Artículos
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