English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/134176
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Protein-protein interaction networks: unraveling the wiring of molecular machines within the cell

AuthorsDe Las Rivas, Javier ; Fontanillo, Celia
Protein interaction
Protein hub
Issue Date2012
PublisherOxford University Press
CitationBriefings in Functional Genomics 11(6): 489-496 (2012)
AbstractMapping and understanding of the protein interaction networks with their key modules and hubs can provide deeper insights into the molecular machinery underlying complex phenotypes. In this article, we present the basic characteristics and definitions of protein networks, starting with a distinction of the different types of associations between proteins. We focus the review on protein-protein interactions (PPIs), a subset of associations defined as physical contacts between proteins that occur by selective molecular docking in a particular biological context. We present such definition as opposed to other types of protein associations derived from regulatory, genetic, structural or functional relations. To determine PPIs, a variety of binary and co-complex methods exist; however, not all the technologies provide the same information and data quality. A way of increasing confidence in a given protein interaction is to integrate orthogonal experimental evidences. The use of several complementary methods testing each single interaction assesses the accuracy of PPI data and tries to minimize the occurrence of false interactions. Following this approach there have been important efforts to unify primary databases of experimentally proven PPIs into integrated databases. These meta-databases provide a measure of the confidence of interactions based on the number of experimental proofs that report them. As a conclusion, we can state that integrated information allows the building of more reliable interaction networks. Identification of communities, cliques, modules and hubs by analysing the topological parameters and graph properties of the protein networks allows the discovery of central/critical nodes, which are candidates to regulate cellular flux and dynamics.
DescriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.
Publisher version (URL)http://dx.doi.org/10.1093/bfgp/els036
Identifiersdoi: 10.1093/bfgp/els036
issn: 2041-2649
e-issn: 2041-2657
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
Proteinprotein.pdf116,67 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.