English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/134157
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Common Infectious Agents and Monoclonal B-Cell Lymphocytosis: A Cross-Sectional Epidemiological Study among Healthy Adults

AuthorsCasabonne, Delphine; Almeida, Julia ; Nieto, Wendy G.; Rodríguez-Caballero, Arancha; Orfao, Alberto
Issue Date2012
PublisherPublic Library of Science
CitationPLoS ONE 7(12): e52808 (2012)
Abstract[Background]: Risk factors associated with monoclonal B-cell lymphocytosis (MBL), a potential precursor of chronic lymphocytic leukaemia (CLL), remain unknown. [Methods]: Using a cross-sectional study design, we investigated demographic, medical and behavioural risk factors associated with MBL. >Low-count> MBL (cases) were defined as individuals with very low median absolute count of clonal B-cells, identified from screening of healthy individuals and the remainder classified as controls. 452 individuals completed a questionnaire with their general practitioner, both blind to the MBL status of the subject. Odds ratios (OR) and 95% confidence interval (CI) for MBL were estimated by means of unconditional logistic regression adjusted for confounding factors. [Results]: MBL were detected in 72/452 subjects (16%). Increasing age was strongly associated with MBL (P-trend<0.001). MBL was significantly less common among individuals vaccinated against pneumococcal or influenza (OR 0.49, 95% confidence interval (CI): 0.25 to 0.95; P-value = 0.03 and OR: 0.52, 95% CI: 0.29 to 0.93, P-value = 0.03, respectively). Albeit based on small numbers, cases were more likely to report infectious diseases among their children, respiratory disease among their siblings and personal history of pneumonia and meningitis. No other distinguishing epidemiological features were identified except for family history of cancer and an inverse relationship with diabetes treatment. All associations described above were retained after restricting the analysis to CLL-like MBL. [Conclusion]: Overall, these findings suggest that exposure to infectious agents leading to serious clinical manifestations in the patient or its surroundings may trigger immune events leading to MBL. This exploratory study provides initial insights and directions for future research related to MBL, a potential precursor of chronic lymphocytic leukaemia. Further work is warranted to confirm these findings.
DescriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.-- Primary Health Care Group of Salamanca for the Study of MBL: et al.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0052808
URIhttp://hdl.handle.net/10261/134157
DOI10.1371/journal.pone.0052808
Identifiersdoi: 10.1371/journal.pone.0052808
issn: 1932-6203
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
Healthy Adults.PDF1,2 MBAdobe PDFThumbnail
View/Open
Show full item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.