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Title

Evaluation of onion as a functional ingredient in the prevention of metabolic impairments associated to diet-induced hypercholesterolaemia using a multiplatform approach based on LC-MS, CE-MS and GC-MS

AuthorsGonzález Peña, Diana ; Dudzik, Danuta; Colina Coca, Clara ; Ancos, Begoña de ; García, Antonia; Barbas, Coral; Sánchez-Moreno, Concepción
KeywordsNutraceuticals
Onion metabolism
Plasma fingerprinting
Metabolomics
Functional foods
High-cholesterol diet
Issue Date2015
PublisherElsevier
CitationJournal of Functional Foods 19: 363- 375 (2015)
AbstractThe preventive and modulating effects of onion in metabolites affected by a high-cholesterol diet and related to molecular pathway dysfunction were examined. Plasma obtained from 24 male Wistar rats after seven weeks of experimental feeding was analysed through a non-targeted multiplatform metabolomics approach based on LC-MS, CE-MS and GC-MS methods. A cross-comparison of the three metabolic profiles [I) control (C) group, II) high-cholesterol (HC) group and III) high-cholesterol enriched with onion (HCO) group] pointed out two sulphur metabolites, S-methyl-L-cysteine and S-methylcysteine sulphoxide, as markers of onion intake and evidenced the possibilities to regulate key metabolites. Thus, the methylation cycle, arginine and tryptophan pathways, the modulation of 3-methylhistidine, as well as the routes involved in the glycerophospholipids transformation have been highlighted. This study suggests that onion's biologically active compounds take a prominent role in ameliorating hypercholesterolaemia and related complications through the regulation of altered metabolic pathways.
URIhttp://hdl.handle.net/10261/133540
DOI10.1016/j.jff.2015.09.033
Identifiersdoi: 10.1016/j.jff.2015.09.033
issn: 1756-4646
Appears in Collections:(ICTAN) Artículos
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