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Title

Critical role for Fat/Hippo and IIS/Akt pathways downstream of Ultrabithorax during haltere specification in Drosophila

AuthorsSing, Savista; Sánchez-Herrero, Ernesto ; Shashidhara, L.S.
KeywordsYorkie
Cell size
Organ size
Expanded
Hox genes
Haltere
Wing
Issue Date20-Aug-2015
CitationMechanisms of Development 138: 198- 209 (2015)
Abstract© 2015 Elsevier Ireland Ltd. In Drosophila, differential development of wing and haltere, which differ in cell size, number and morphology, is dependent on the function of Hox gene Ultrabithorax (Ubx). Here we report our studies on Ubx-mediated regulation of the Fat/Hippo and IIS/dAkt pathways, which control cell number and cell size during development. Over-expression of Yki or down regulation of negative components of the Fat/Hippo pathway, such as expanded, caused considerable increase in haltere size, mainly due to increase in cell number. These phenotypes were also associated with the activation of Akt pathways in developing haltere. Although activation of Akt alone did not affect the cell size or the organ size, we observed dramatic increase in haltere size when Akt was activated in the background where expanded is down regulated. This was associated with the increase in both cell size and cell number. The organ appeared flatter than wildtype haltere and the trichome morphology and spacing resembled that of wing suggesting homeotic transformations. Thus, our results suggest a link between cellular growth and pattern formation and the final differentiated state of the organ.
URIhttp://hdl.handle.net/10261/133365
Identifiersissn: 1872-6356
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