Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/133225
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | New cinnamic – N-benzylpiperidine and cinnamic – N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties |
Autor: | Estrada, Martín CSIC ORCID CVN; Herrera-Arozamena, Clara CSIC ORCID CVN; Pérez, Concepción CSIC ORCID; Viña, Dolores; Romero, Alejandro CSIC ORCID; Morales-García, José A. CSIC ORCID; Pérez Castillo, Ana CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID | Palabras clave: | Cinnamic-based hybrid Antioxidants Neuroprotectants Neurogenic agents Human cholinesterases Human monoamine oxidases |
Fecha de publicación: | 4-oct-2016 | Editor: | Elsevier | Citación: | European Journal of Medicinal Chemistry 121(4): 376–386 (2016) | Resumen: | Here we describe new families of multi-target directed ligands obtained by linking antioxidant cinnamic-related structures with N-benzylpiperidine (NBP) or N,N-dibenzyl(N-methyl)amine (DBMA) fragments. Resulting hybrids, in addition to their antioxidant and neuroprotective properties against mitochondrial oxidative stress, are active at relevant molecular targets in Alzheimer’s disease, such as cholinesterases (hAChE and hBuChE) and monoamine oxidases (hMAO-A and hMAO-B). Hybrids derived from umbellic – NBP (8), caffeic – NBP (9), and ferulic – DBMA (12) displayed balanced biological profiles, with IC50s in the low-micromolar and submicromolar range for hChEs and hMAOs, and an antioxidant potency comparable to vitamin E. Moreover, the caffeic – NBP hybrid 9 is able to improve the differentiation of adult SGZ-derived neural stem cells into a neuronal phenotype in vitro. | Versión del editor: | http://dx.doi.org/10.1016/j.ejmech.2016.05.055 | URI: | http://hdl.handle.net/10261/133225 | DOI: | 10.1016/j.ejmech.2016.05.055 | ISSN: | 0223-5234 | E-ISSN: | 1768-3254 |
Aparece en las colecciones: | (IQM) Artículos (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
New cinnamic hybrids as Alzheimer-directed multitarget drugs.pdf | 830,41 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
45
checked on 12-mar-2024
WEB OF SCIENCETM
Citations
45
checked on 27-feb-2024
Page view(s)
716
checked on 18-mar-2024
Download(s)
599
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.