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dc.contributor.authorTejedor, Daviden_US
dc.contributor.authorSantos-Expósito, Aliciaen_US
dc.contributor.authorGarcía-Tellado, Fernandoen_US
dc.date.accessioned2009-05-28T07:16:21Z-
dc.date.available2009-05-28T07:16:21Z-
dc.date.issued2006-06-12en_US
dc.identifier.citationSynlett 2006(10): 1607-1609 (2006)en_US
dc.identifier.issn0936-5214-
dc.identifier.urihttp://hdl.handle.net/10261/13273-
dc.description3 pages, 1 figure, 1 table, 2 schemes.-
dc.description.abstractA one-pot, convenient and general access to 5-sp2-substituted and 5,5-disubstituted tetronic acids is described. The protocol embodies two consecutive chemical events: a Michael addition of pyrrolidine on a secondary or tertiary γ-hydroxy-α,β-alkynyl ester derivative to give the corresponding enamine, and the subsequent acid-catalyzed hydrolysis-lactonization of this intermediate to afford the tetronic acid derivative.-
dc.description.sponsorshipThis research was supported by the Spanish Ministerio de Educación y Ciencia and the European Regional Development Fund (CTQ2005-09074-C02-02). F.G.T. thanks the Instituto Canario de Investigación del Cáncer for financial support (ICIC-GI nº 10/2005: ISCiii, RTICCC C03/10).-
dc.format.extent2373 bytes-
dc.format.extent73435 bytes-
dc.format.mimetypetext/plain-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherThieme-
dc.rightsclosedAccessen_US
dc.subjectAlkynes-
dc.subjectLactones-
dc.subjectAminations-
dc.subjectCyclizations-
dc.subjectMichael additions-
dc.titleA convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acidsen_US
dc.typeartículoen_US
dc.identifier.doi10.1055/s-2006-941596-
dc.relation.publisherversionhttp://dx.doi.org/10.1055/s-2006-941596-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderInstituto Canario de Investigación del Cáncer-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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