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Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure-activity relationship study

AuthorsPadrón, José M.; Tejedor, David ; Santos-Expósito, Alicia; García-Tellado, Fernando ; Martín, Víctor S.; Villar, Jesús
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Antitumor drugs
Issue Date12-Apr-2005
CitationBioorganic and Medicinal Chemistry Letters 15(10): 2487-2490 (2005)
AbstractA number of tetrasubstituted pyrrole derivatives have been synthesized and evaluated for their in vitro antiproliferative activities using the human promyelocytic leukemia cell line HL60. Tetrasubstituted pyrroles are obtained by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. Active compounds exhibited GI(50) values in the range 4–45 μM, and only six products showed TGI values within the evaluation range. A structure–activity relationship is also discussed.
Description4 pages, 1 table, 3 schemes.-- PMID: 15863302 [PubMed].-- Printed version published May 16, 2005.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2005.03.069
Appears in Collections:(IPNA) Artículos
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