English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/13265
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure-activity relationship study

AuthorsPadrón, José M.; Tejedor, David ; Santos-Expósito, Alicia; García-Tellado, Fernando ; Martín, Víctor S.; Villar, Jesús
KeywordsPyrroles
Privileged structure
Leukemia
Antitumor drugs
Issue Date12-Apr-2005
PublisherElsevier
CitationBioorganic and Medicinal Chemistry Letters 15(10): 2487-2490 (2005)
AbstractA number of tetrasubstituted pyrrole derivatives have been synthesized and evaluated for their in vitro antiproliferative activities using the human promyelocytic leukemia cell line HL60. Tetrasubstituted pyrroles are obtained by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. Active compounds exhibited GI(50) values in the range 4–45 μM, and only six products showed TGI values within the evaluation range. A structure–activity relationship is also discussed.
Description4 pages, 1 table, 3 schemes.-- PMID: 15863302 [PubMed].-- Printed version published May 16, 2005.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2005.03.069
URIhttp://hdl.handle.net/10261/13265
DOI10.1016/j.bmcl.2005.03.069
ISSN0960-894X
Appears in Collections:(IPNA) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.