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Título: | Physics of nanomechanical spectrometry of viruses |
Autor: | Ruz Martínez, José Jaime CSIC ORCID; Tamayo de Miguel, Francisco Javier CSIC ORCID; Pini, Valerio CSIC ORCID; Kosaka, Priscila M. CSIC ORCID ; Calleja, Montserrat CSIC ORCID | Fecha de publicación: | 13-ago-2014 | Editor: | Nature Publishing Group | Citación: | Scientific Reports 4: 6051 (2014) | Resumen: | There is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a detailed theoretical analysis to calculate the resonance frequency shift induced by the mechanical stiffness of viral nanotubes. The model accounts for the high surface-to-volume ratio featured by single biological entities, the shape anisotropy and the interfacial adhesion. The model is applied to the case in which tobacco mosaic virus is randomly delivered to a silicon nitride cantilever. The theoretical framework opens the door to a novel paradigm for biological spectrometry as well as for measuring the Young's modulus of biological systems with minimal strains. | Versión del editor: | http://dx.doi.org/10.1038/srep06051 | URI: | http://hdl.handle.net/10261/132593 | DOI: | 10.1038/srep06051 | Identificadores: | issn: 2045-2322 |
Aparece en las colecciones: | (IMN-CNM) Artículos |
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spectrometry_viruses_Ruz.pdf | 1,79 MB | Adobe PDF | Visualizar/Abrir |
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