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Title

Physics of nanomechanical spectrometry of viruses

AuthorsRuz Martínez, José Jaime ; Tamayo de Miguel, Francisco Javier ; Pini, Valerio ; Kosaka, Priscila M. ; Calleja, Montserrat
Issue Date13-Aug-2014
PublisherNature Publishing Group
CitationScientific Reports 4: 6051 (2014)
AbstractThere is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a detailed theoretical analysis to calculate the resonance frequency shift induced by the mechanical stiffness of viral nanotubes. The model accounts for the high surface-to-volume ratio featured by single biological entities, the shape anisotropy and the interfacial adhesion. The model is applied to the case in which tobacco mosaic virus is randomly delivered to a silicon nitride cantilever. The theoretical framework opens the door to a novel paradigm for biological spectrometry as well as for measuring the Young's modulus of biological systems with minimal strains.
Publisher version (URL)http://dx.doi.org/10.1038/srep06051
URIhttp://hdl.handle.net/10261/132593
DOI10.1038/srep06051
Identifiersissn: 2045-2322
Appears in Collections:(IMN-CNM) Artículos
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